Integrated Bimodal Waveguide Interferometric Biosensor for Label-Free Analysis


AU: 
Zinoviev, KE; Gonzalez-Guerrero, AB; Dominguez, C; Lechuga, LM
SO: 
JOURNAL OF LIGHTWAVE TECHNOLOGY
GTQ Authors: 
VL: 
29
IS: 
13
BP: 
1926
EP: 
1930
PY: 
2011
SN: 
0733-8724
Impact: 
2.26
Year IF: 
2010
Abstract: 

The performance of an interferometric device based on integrated Bimodal Waveguides (BiMW) for sensing is demonstrated. The sensors are fabricated using standard silicon technology and can achieve a detection limit of 2.5.10(-7) RIU for homogeneous sensing, rendering in a very high sensitive device. The applicability of the bimodal waveguide interferometer as label-free biosensor has been demonstrated by the real-time monitoring of the biomolecular interaction of BSA and antiBSA. Due to their simplicity, the interferometric devices could be further integrated in complete lab-on-a-chip platforms for point-of-care diagnostics showing them as a powerful instrument for biochemical analysis.

DT: 
Article en revistes indexades
Percentil: 
HIGH
Percentil Year: 
2010
Category: 
OPTICS
KW: 
Bimodal waveguide; evanescent wave detection; integrated optics; optical biosensors; waveguides