Nanophotonic lab-on-a-chip platforms including novel bimodal interferometers, microfluidics and grating couplers


AU: 
Duval, D; Gonzalez-Guerrero, AB; Dante, S; Osmond, J; Monge, R; Fernandez, LJ; Zinoviev, KE; Dominguez, C ; Lechuga, LM
SO: 
LAB ON A CHIP
Autors del GTQ: 
VL: 
12
IS: 
11
BP: 
1987
EP: 
1994
PY: 
2012
SN: 
473-0197
Impact: 
6.26
Any IF: 
2010
Resum: 

One of the main limitations for achieving truly lab-on-a-chip (LOC) devices for point-of-care diagnosis is the incorporation of the "on-chip" detection. Indeed, most of the state-of-the-art LOC devices usually require complex read-out instrumentation, losing the main advantages of portability and simplicity. In this context, we present our last advances towards the achievement of a portable and label-free LOC platform with highly sensitive "on-chip" detection by using nanophotonic biosensors. Bimodal waveguide interferometers fabricated by standard silicon processes have been integrated with sub-micronic grating couplers for efficient light in-coupling, showing a phase resolution of 6.6 x 10(-4) x 2 pi rad and a limit of detection of 3.3 x 10(-7) refractive index unit (RIU) in bulk. A 3D network of SU-8 polymer microfluidics monolithically assembled at the wafer-level was included, ensuring perfect sealing and compact packaging. To overcome some of the drawbacks inherent to interferometric read-outs, a novel all-optical wavelength modulation system has been implemented, providing a linear response and a direct read-out of the phase variation. Sensitivity, specificity and reproducibility of the wavelength modulated BiMW sensor has been demonstrated through the label-free immunodetection of the human hormone hTSH at picomolar level using a reliable biofunctionalization process.

DT: 
Article en revistes indexades
Percentil: 
HIGH
Any Percentil: 
2010
Categoria: 
CHEMISTRY, MULTIDISCIPLINARY